HA在皮肤中的生理功能

1.保水
Hyaluronic Acid guarantees the water function in the skin organization is one of its most important physiological functions, Its theory guarantees water number Above 500ml/g, contracts in the organization in the knot the reality to guarantee the water number approximately.HA when high density, its long molecular chain interweaves mutually the lattice, adds it with the water hydrogen bond union, thus plays very strongly guarantees the water role.HA outside the butcher in the matrix main function is The maintenance moisture content, with other sulphating mucopolysaccharide and the collogen, the elastic egg waits in vain the fibrous protein, composes together including outside the massive moisture content butcher the porodine matrix, becomes the cell metabolism the material interchange medium.This kind of watery porodine matrix, causes the skin to be pliable but hard to break, the rich elasticity, the sufficient moisture content causes the flesh smoothly delicate.When skin moist feeling v透明质酸保证皮肤组织中的水分功能是其最重要的生理功能之一,其理论上保证水分含量在XNUMXml / g以上,在组织中收缩的事实保证了水分含量。高密度时,HA,它的长分子链将晶格相互交织,并与水的氢键结合,从而起到非常有力的保证水的作用。屠夫外的HA在基质中的主要功能是维持水分,与其他硫酸化粘多糖和胶原蛋白一起,弹性卵白蛋白纤维蛋白,包括大量的水分在内屠宰的猪rod素基质组成,成为细胞新陈代谢的物质交换介质。这种水po素的基质,使皮肤柔软但不易断裂,丰富的弹性,充足的水分使肌肤光滑细腻。 anishing, appears the wrinkle, some people thought is which causes as a result of the HA reduction.Along with the age growth, in the skin the HA content reduces, the skin organization cell and the intercellular space moisture content reduces, the space which by HA the intercellular space which primarily composes the porodine matrix fills to reduce, causes the cell arrangement to be close, the collogen dehydration hardens, causes the skin to be rough, loses the elasticity.Therefore the moisture content regarding the skin health is very important.随着年龄的增长,皮肤中的HA含量降低,皮肤组织细胞和细胞间空间的水分含量降低,从而导致HA的减少。 HA主要组成极化蛋白基质的细胞间隙减少,使细胞排列紧密,胶原蛋白脱水变硬,使皮肤粗糙,失去弹性。因此水分对于皮肤健康非常重要。 Guarantees Shui Baoshi always is the skin care puts on make-up skin care cosmetics) one of most main research topics, also is one of skin appliances main functions.保证水硬性始终是皮肤护理化妆化妆品的最主要研究课题之一,也是皮肤用具的主要功能之一。
2.维护细胞外空间
HA和硫酸软骨素,硫酸皮肤元素等基质成分并含有大量水分,共同形成肉外层空间,有利于营养供应和代谢废物的排放,表皮细胞的迁移,免疫细胞(朗格很少有Si细胞与真皮中的淋巴薄层相差。
3.大离子优点
在HA成员链上,每个双糖单元均带有一个负电荷(一个C00ˉ),使其具有类似的离子交换药物制备功能,在调节池周围具有正离子流动和密度。
4.参与角化细胞的变化过程
HA在表皮层紧密参与角质形成细胞的增殖,向外层迁移和分化等,调节整个变化过程,但其自身的代谢激素,生长因子和细胞激活剂(细胞分裂素)等信号员调节。关于黄原酸(视黄酸) )和表皮因表皮生长因子(EGF)生长而刺激HA的生物合成,增加皮肤中HA含量,但氢化则可能使松树的功能相反。因此,从美容和保护皮肤的角度出发,皮肤表面尽量少使用肾上腺皮质激素类药物。
5.受体联合会影响
A与表皮细胞表面的CD44受体结合,促进表皮细胞正常分化。CD44受体是表皮正常生长和分裂的标志,当皮肤患有鳞状细胞癌时,角质细胞分裂停止,随CD44脱落受体从细胞表面还原与HA有关。HA是细胞存活的信号物质,它与角蛋白细胞表面受体结合,具有一种刺激作用,能减缓对角质的分化,最终消亡。
6.自由基对人体的影响
透明质酸在表皮中的活性氧肥皂,在阳光下紫外线的照射下,由该碱产生,保护皮肤免除其邪恶,被称为高效自由基的清道夫。氧自由基可引起脂肪过氧化, HA和氧自由基有反应,自由基被清除,HA被降解。因此HA还具有防止日晒的功能。