索拉非尼托西酯

[CAS号] 475207-59-1
[分子量] 637.03
[分子式] C21H16ClF3N4O3.C7H8SO3  
[外观]白色至类白色结晶性粉末
[密度] 1.454 g / cm3
[沸点] 523.3°C在760 mmHg
[闪点] 270.3°C
关于甲苯磺酸索拉非尼
Sorafenib tosylate is a new multi-targeted anti-tumor drug developed by Bayer AG in Germany that can act on both tumor cells and tumor blood vessels.甲苯磺酸索拉非尼是德国拜耳公司开发的一种新型的多靶点抗肿瘤药物，可同时作用于肿瘤细胞和肿瘤血管。 It has a dual antitumor effect: it can directly inhibit the proliferation of tumor cells by blocking the cell signaling pathway mediated by RAF / MEK / ERK, and can also inhibit the growth of tumor cells by inhibiting VEGF and platelet-derived growth factor (PDGF) receptors Blocking the formation of neovascularization, indirectly inhibiting the growth of tumor cells.它具有双重抗肿瘤作用：它可以通过阻断RAF / MEK / ERK介导的细胞信号通路直接抑制肿瘤细胞的增殖，还可以通过抑制VEGF和血小板源性生长因子（PDGF）抑制肿瘤细胞的生长。 ）受体阻断新血管形成的形成，间接抑制肿瘤细胞的生长。
甲苯磺酸索拉非尼用于治疗原发性肾癌，晚期原发性肝癌和放射性碘耐药的晚期甲状腺癌。