猫薄荷抗肾癌

Englerin A是最近在非洲植物中发现的天然产物，对肾癌细胞具有高毒性，而对其他细胞则具有低毒性。 This compound is potentially qualified for further evaluation toward an application in cancer therapy.该化合物可能有资格进一步评估其在癌症治疗中的应用。 Mathias Christmann, a professor of organic chemistry at TU Dortmund, have noticed that one ingredient of catmint has a structure similar to that of englerin A. Afterwards, he and his colleagues Dr. Matthieu Willot and graduate student Lea Radtke started a program to convert nepetalactone, the active substance of catmint, or Nepeta cataria, into englerin A. As a result, the molecular structure of the starting material - nepetalactone, is altered in the laboratory step-by-step, finally culminating in the target molecule (englerin A).多特蒙德大学有机化学教授马蒂亚斯·克里斯特曼（Mathias Christmann）注意到，猫薄荷的一种成分具有与英格陵兰A相似的结构。此后，他和他的同事Matthieu Willot博士以及研究生Lea Radtke启动了一个转化荆芥内酯的计划，即猫薄荷或荆芥的活性物质，转化为英格列宁A。结果，原料-荆芥内酯的分子结构在实验室中逐步改变，最终达到目标分子（英格列宁A） 。 The first successful total synthesis, meaning the synthetic production of englerin A on the basis of catmint oil, was completed in summer 2009.首次成功的全合成，即在猫薄荷油的基础上合成恩格尔林A的生产，已于XNUMX年夏季完成。