什么是白屈菜红碱

The benzophenanthridine alkaloid chelerythrine is extracted from the plant Chelidonium majus.苯并菲啶生物碱白屈菜红碱从植物白屈菜中提取。 It has formerly been proven to be a potent and selective inhibitor of the serine/threonine-specific protein kinase C (PKC).以前已证明它是丝氨酸/苏氨酸特异性蛋白激酶C（PKC）的有效和选择性抑制剂。 Recently, it has been identified as a Bcl-xL inhibitor which is able to trigger apoptosis via direct action on mitochondria.最近，已鉴定出它是一种Bcl-xL抑制剂，它能够通过直接作用于线粒体来触发细胞凋亡。 Chelerythrine rapidly induced pyknosis, shrinkage and subsequent cell death in cardiac myocytes and caused cytochrome c release from mitochondria, which was observably inhibited in the presence of NAC, suggesting that ROS mediates chelerythrine-induced cytochrome c release.白屈菜红碱在心肌细胞中迅速诱导凝缩，萎缩和随后的细胞死亡，并导致线粒体释放细胞色素c，在NAC存在下可观察到抑制，提示ROS介导了白屈菜红素诱导的细胞色素c释放。