甲氧苄啶

[同义词] Proloprim; Trimpex; 细菌素
[CAS号 ] 738-70-5  
[分子式] C14H18N4O3
[分子量] 290.323
[外观]白色粉末
[纯度] 99％min
[主要功能] 
1.可用作协同抗菌药物； it can also be used for treating bacterial infections and coccidiosis in poultry.它也可以用于治疗家禽的细菌感染和球虫病。 
2.它是一种新型的口服广谱抗生素。 It has a similar antibacterial spectrum with sulfa drugs but with a stronger potency.它具有与磺胺类药物相似的抗菌谱，但具有更强的效力。 It is effective in treating a variety of Gram positive and negative bacteria.有效治疗多种革兰氏阳性和阴性细菌。 Since the bacteria is easy to evolve drug resistance to this product, it is not suitable to be used alone as an antimicrobial drug.由于细菌易于产生对该产品的耐药性，因此不适合单独用作抗菌药物。 The combination between trimethoprim and sulfa drugs can enhance the antibacterial activity by several times to several dozens of times.甲氧苄啶和磺胺药的结合可以将抗菌活性提高数倍至数十倍。 The product is mainly used for being as the synergistic drugs for sulfonamide drugs with a general ratio of 1: 5 for usage.该产品主要用作磺胺类药物的增效剂，一般使用比例为XNUMX：XNUMX。 It can also be used as a veterinary drug for treatment of avian sepsis caused by Escherichia coli, salmonellosis, fowl typhoid, cholera, and respiratory system secondary bacterial infections.它也可以用作兽药来治疗由大肠杆菌，沙门氏菌病，禽伤寒，霍乱和呼吸系统继发性细菌感染引起的禽败血症。 It can also be used for the treatment of coccidiosis.它也可以用于治疗球虫病。  
[应用]
Used as antibacterial synergistic drugs;用作抗菌协同药物； treat respiratory tract infections, urinary tract infections and intestinal infections when being used alone.单独使用时，可治疗呼吸道感染，泌尿道感染和肠道感染。
关于甲氧苄啶
Trimethoprim is a lipophilic weakly basic pyrimethamine bacteriostatic agent, white or off-white crystalline powder at room temperature, odorless, bitter, slightly soluble in chloroform, slightly soluble in ethanol or acetone, almost insoluble in water, easy to use in glacial acetic acid Dissolved.甲氧苄啶是一种亲脂性弱碱性的乙胺嘧啶抑菌剂，室温下为白色或灰白色结晶粉末，无臭，苦味，微溶于氯仿，微溶于乙醇或丙酮，几乎不溶于水，易在冰醋酸中溶解。 The antibacterial spectrum is similar to that of sulfa drugs, but it has strong antibacterial effect.抗菌谱与磺胺类药物相似，但具有很强的抗菌作用。 It is effective against Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Staphylococcus aureus, and various Gram-positive and negative bacteria, but it is not effective against Pseudomonas aeruginosa infection.它对大肠杆菌，奇异变形杆菌，肺炎克雷伯菌，金黄色葡萄球菌以及各种革兰氏阳性和阴性细菌有效，但对铜绿假单胞菌感染无效。 Often less than 10mg / L, single use is easy to cause bacterial resistance, it is generally not used alone, mainly with sulfa drugs constitute a compound preparation, clinically used to treat urinary tract infections, intestinal infections, respiratory tract infections, dysentery, enteritis , typhoid, meningitis, otitis media, meningitis, sepsis and soft tissue infections.经常低于XNUMXmg / L，单次使用容易引起细菌耐药，一般不单独使用，主要与磺胺类药物构成复合制剂，临床上用于治疗尿路感染，肠道感染，呼吸道感染，痢疾，肠炎，伤寒，脑膜炎，中耳炎，脑膜炎，败血症和软组织感染。 The efficacy of typhoid fever and paratyphoid fever is not lower than that of ampicillin, and it can also be combined with long-acting sulfa drugs for the prevention and treatment of drug-resistant falciparum malaria.伤寒和副伤寒的疗效不低于氨苄西林，它也可以与长效磺胺类药物联合使用，以预防和治疗耐药性恶性疟疾。