福斯高林

[CAS号] 66428-89-5
[分子式] C22H34O7
[分子量] 410.51
[溶解度]溶于乙醇，氯仿和DMSO等有机溶剂
[植物来源] forleus forskohlii（威尔士）。
[外观]浅黄色粉末
[药理作用]减肥，塑身。
关于福斯科林
Forskolin is a diterpene derivative derived from the activation of adenylate cyclase by the plant larynx.福斯高林是一种二萜衍生物，由植物喉腺激活腺苷酸环化酶而衍生。 It is a hydrophobic activator that stimulates adenylate cyclase activity in mammalian cells.它是一种疏水性激活剂，可刺激哺乳动物细胞中的腺苷酸环化酶活性。 The anti-inflammatory and anti-oxidative effects of forskolin are due to inhibition of macrophage activation, thereby reducing the levels of thromboxane B2 and superoxide.毛喉素的抗炎和抗氧化作用归因于巨噬细胞活化的抑制，从而降低了血栓烷BXNUMX和超氧化物的水平。 This property makes forskolin an effective drug for the treatment of heart disease, high blood pressure, diabetes and asthma.此特性使福司可林成为治疗心脏病，高血压，糖尿病和哮喘的有效药物。 In vitro experiments showed that the activation of adenylate cyclase by Forskolin resulted in a significant increase in cyclic AMP levels in a variety of eukaryotic cells.体外实验表明，福斯科林对腺苷酸环化酶的激活导致各种真核细胞中环AMP含量的显着增加。 The low concentration of forskolin can increase the intracellular cyclic AMP in a small amount by enhancing the activation of adenylate cyclase in intact cells.低浓度的佛司可林可以通过增强完整细胞中腺苷酸环化酶的活化来少量增加细胞内环状AMP。