甲苯磺丁脲

[CAS号] 64-77-7
[分子式] C12H18N2O3S
[分子量] 270.35
[外观]白色结晶性粉末
[熔点]128-130ºC
[相对密度] 1.184 g / cm3
关于甲苯磺丁酰胺
Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic drug sold under the brand name Orinase.甲苯磺丁酰胺是第一代钾通道阻滞剂，磺脲类口服降血糖药，商品名为Orinase。 This drug may be used in the management of type II diabetes if diet alone is not effective.如果仅饮食无效，则该药物可用于II型糖尿病的治疗。 Tolbutamide stimulates the secretion of insulin by the pancreas.甲苯磺丁酰胺可刺激胰腺分泌胰岛素。 Since the pancreas must synthesize insulin in order for this drug to work, it is not effective in the management of type I diabetes.由于胰腺必须合成胰岛素才能使这种药物起作用，因此它在I型糖尿病的治疗中无效。 It is not routinely used due to a higher incidence of adverse effects compared to newer second generation sulfonylureas, such as glyburide.与较新的第二代磺酰脲类药物（如格列本脲）相比，由于不良反应的发生率更高，因此通常不使用这种药物。