辛伐他汀

[CAS号] 79902-63-9
[ Synonyms ] (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl 2,2-dimethyl-butanoate
[分子式] C25H38O5 
[分子量] 418.57 
[外观]白色结晶粉末
[密度] 1.11 g / cm3
[熔点]139ºC
[沸点]564.9ºC，760 mmHg
[闪点]184.8ºC
[测定] 98％min（HPLC）
[功能与应用] 
（1）辛伐他汀的主要用途是治疗血脂异常和预防心血管疾病。
（2）也可用于冠心病患者。
关于辛伐他汀
控制血液中的胆固醇水平并预防心血管疾病。
Simvastatin is a hypolipidemic drug used with exercise, diet, and weight-loss to control elevated cholesterol, or hypercholesterolemia.辛伐他汀是一种降血脂药物，可与运动，饮食和减肥一起使用，以控制胆固醇升高或高胆固醇血症。 It is a member of the statin class of pharmaceuticals.它是他汀类药物的成员。
Simvastatin is an HMGCR (HMG-CoA reductase) inhibitor with anti-proliferative properties.辛伐他汀是具有抗增殖特性的HMGCR（HMG-CoA还原酶）抑制剂。 This compound has been shown to modulate purified bovine pituitary 20 S proteasome via mild stimulation of chymotrypsin-like activity and inhibition of peptidylglutamylpeptide hydrolyzing activity.已显示该化合物通过轻微刺激胰凝乳蛋白酶样活性和抑制肽基谷氨酰胺肽水解活性来调节纯化的牛垂体4 S蛋白酶体。 Mechanistic studies suggest that Simvastatin decreases CDK2 and CDK21 kinase activities and represses high glucose-induced Rho A (Rho GTPase)/p50 signaling in mesangial cells.机理研究表明，辛伐他汀降低了系膜细胞中CDK13和CDKXNUMX激酶的活性，并抑制了高葡萄糖诱导的Rho A（Rho GTPase）/ pXNUMX信号传导。 Simvastatin also potentiates apoptosis in human myeloid leukemia cells via the suppression of TNF-induced NF-κB activation (ICXNUMX ~ XNUMX µM).辛伐他汀还可以通过抑制TNF诱导的NF-κB活化（ICXNUMX〜XNUMX µM）来增强人类髓样白血病细胞的凋亡。